LG Sciences - 4-Andro - 75mg - 60 Tablets

LG Sciences 4-Andro is a non-methylated prohormone containing 75mg of 3β-hydroxy-androst-4-ene-17-one per tablet, a DHEA-derived compound that converts to testosterone through a two-step enzymatic process in the body. Delivered via LG Sciences' liposome tablet technology for improved absorption, it is a cycle-based supplement designed for experienced adult men pursuing serious muscle and strength goals, with mandatory post-cycle therapy following each cycle.

What Is LG Sciences 4-Andro?

LG Sciences 4-Andro is a non-methylated prohormone supplement containing 75mg of 3β-hydroxy-androst-4-ene-17-one, commonly referred to as 4-Androsterone or 4-DHEA per tablet. It comes in a 60-tablet bottle delivering 60 single-tablet servings, or 30 servings at the two-tablet advanced dose.

A prohormone is a compound that the body converts into a target hormone through enzymatic processes. In the case of 4-Andro, the conversion target is testosterone. It is not testosterone itself, it is a precursor that the body processes into testosterone after ingestion.

4-Andro is a DHEA-derived compound. DHEA (dehydroepiandrosterone) is a steroid hormone naturally produced by the adrenal glands and serves as a precursor to both testosterone and estrogen in the body. The 4-Andro molecule is a structural modification of DHEA specifically oriented toward the testosterone conversion pathway.

This is a cycle-based supplement. It is not a daily wellness product used indefinitely. Each cycle of 4-8 weeks must be followed by post-cycle therapy. This distinction is critical to using it safely.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

How 4-Andro Works: The Conversion Pathway?

4-Andro converts to testosterone through a well-defined two-step enzymatic process:

Step 1: 3β-hydroxy-androst-4-ene-17-one → Androstenedione
(via 3β-hydroxysteroid dehydrogenase)

Step 2: Androstenedione → Testosterone
(via 17β-hydroxysteroid dehydrogenase)

Both conversion enzymes are naturally present in human tissue. The compound does not bypass or override this process it enters the body's existing steroid hormone synthesis pathway and is processed accordingly.

This two-step conversion has two practical implications for users:

Conversion rate is not 100%. A portion of the 4-Andro dose is metabolised through other pathways or excreted without completing full conversion to testosterone. The actual testosterone yield from a given oral dose depends on individual metabolic factors, which is one reason why the liposome delivery system LG Sciences uses is relevant.

Aromatization is possible. Testosterone can convert to estrogen through the aromatase enzyme. 4-Andro has a wet-gains profile meaning estrogen conversion is a real consideration, and users who are estrogen-sensitive may benefit from monitoring this during a cycle.

LG Sciences' Liposome Delivery Technology

Most 4-Andro products on the market are basic powder-in-capsule formats. LG Sciences uses a liposome tablet system, which meaningfully separates their product from commodity options in this category.

The delivery matrix includes:

• Phosphatidylcholine 75%: Phosphatidylcholine is the primary component of cell membranes and forms the structure of liposomes tiny lipid-based vesicles that encapsulate the active ingredient. Liposomal delivery protects compounds from degradation during digestion and facilitates more efficient passage through intestinal membranes.
• Hydroxypropyl Beta Cyclodextrin (HPBCD): Cyclodextrins are ring-shaped molecules that form inclusion complexes with poorly water-soluble compounds, improving their dissolution and absorption. HPBCD is specifically used in pharmaceutical and supplement applications to enhance bioavailability of lipophilic (fat-soluble) molecules which steroid-class compounds are.
• Phytosterols: Plant-derived sterols included as part of the liposome matrix structure.

Why this matters: Oral bioavailability of prohormone compounds is naturally limited due to first-pass liver metabolism. By improving absorption at the intestinal level through the liposome and cyclodextrin system, more active compound reaches systemic circulation per tablet compared to unformulated powder alternatives. This is a genuine formulation advantage that justifies the premium positioning of LG Sciences 4-Andro within this category.

Quick Take - Product Essentials

• 75mg of 3β-hydroxy-androst-4-ene-17-one per tablet
• Liposome delivery system with Phosphatidylcholine 75% + HPBCD for enhanced absorption
• Non-methylated does not carry the liver toxicity risk profile of methylated prohormones
• Converts to testosterone via two-step enzymatic pathway
• 60 tablets per bottle 60 days at 1 tablet/day or 30 days at 2 tablets/day
• Cycle-based use with mandatory PCT

Non-Methylated vs. Methylated Prohormones Why It Matters?

If you are researching 4-Andro, you have likely encountered references to methylated prohormones. Understanding the difference is important.

Methylated prohormones contain a methyl group at the 17α position of the steroid molecule. This modification makes the compound resistant to first-pass liver metabolism, improving oral bioavailability but the cost is significant hepatotoxicity. Methylated prohormones place a direct, documented burden on the liver and require liver support supplementation and shorter cycle lengths as a result.

4-Andro is non-methylated. It does not have this structural modification. This means it does not carry the same direct liver toxicity risk profile as methylated prohormones. For users who want the performance support a prohormone offers without the hepatotoxic risk of methylated options, non-methylated compounds like 4-Andro represent a meaningfully different risk profile.

This is also why LG Sciences' liposome delivery system is particularly relevant for non-methylated compounds as it compensates for the lower natural oral bioavailability that comes with not having the methylation modification, without introducing liver strain.

Who Is LG Sciences 4-Andro Designed For?

Minimum age: 21. This is not a product for anyone under 21 years of age.

The reason the minimum age for prohormones is set at 21 not 18 is physiological. The endocrine system continues developing through the early twenties. Introducing exogenous hormone precursors during this period can interfere with the natural hormonal maturation process and cause disruptions that are not easily reversed. Once the body reaches full hormonal maturity at 21+, this risk is significantly reduced.

This product is designed for:

• Adult men aged 21 and above only
• Experienced supplement users with prior knowledge of prohormone cycling
• Those committed to completing the full cycle protocol including PCT
• Men in serious muscle and strength development phases who understand the commitment required

This product is absolutely not appropriate for:

• Anyone under 21 years of age
• Women 4-Andro converts to testosterone, which causes virilisation in women including permanent voice deepening and facial hair growth
• Pregnant or nursing individuals
• Anyone with prostate conditions, prostate cancer history, or BPH
• Anyone with cardiovascular conditions, high blood pressure, or heart disease
• Men with any existing hormonal disorder
• Anyone with liver or kidney conditions
• Anyone currently taking prescription medications without explicit physician clearance
• Athletes competing in tested sports under WADA, USADA, or any major sporting federation, see drug testing section below

Legal Status

4-Androsterone (3β-hydroxy-androst-4-ene-17-one) is currently sold legally as a dietary supplement in the United States. The 2014 Designer Anabolic Steroid Control Act (DASCA) defined and expanded the list of controlled anabolic steroids, but DHEA derivatives including certain 4-DHEA compounds have been classified differently from the explicitly banned anabolic steroids under this legislation.

Important caveats every buyer should understand:

The regulatory landscape for prohormone compounds in the United States is subject to ongoing legal interpretation and potential change. The line between legal DHEA derivatives and controlled anabolic steroids is not always clearly defined, and it is the buyer's responsibility to verify the current legal status of this product in their jurisdiction particularly outside the United States, where laws differ significantly.

LG Sciences is a legitimate supplement company operating within the US market. Retailers including your current store sell this product as a legal dietary supplement under current US regulation.

Drug Testing - Critical Information

• WADA (World Anti-Doping Agency): Testosterone and its precursors, including prohormone compounds that convert to testosterone, are on the WADA prohibited list. Any athlete competing under WADA-compliant testing which covers the Olympics, professional sports governed by WADA rules, and a large number of amateur organisations must not use this product.
• US Military: The Department of Defense and individual branches prohibit the use of prohormone supplements by active military personnel.
• NCAA and Collegiate Sports: Anabolic agents including testosterone precursors are banned across NCAA-governed sports.
• Workplace Drug Testing: Some workplace drug tests screen for elevated testosterone or its metabolites. Using a prohormone that converts to testosterone may affect results depending on the panel used.

If you are subject to any form of drug testing sporting, occupational, or otherwise do not use this product. Consult your sport's governing body or testing authority before using any prohormone.

How to Cycle LG Sciences 4-Andro

As per LG Sciences' stated directions and standard prohormone protocol:

Beginners:

• 1 tablet daily, spaced evenly through the day (morning and evening with food)
• Cycle length: 4-6 weeks
• Mandatory off-period: 4-8 weeks minimum after each cycle
• PCT: Required immediately after the cycle ends

Advanced Users:

• Up to 2 tablets daily, spaced evenly through the day
• Cycle length: 6-8 weeks maximum
• Mandatory off-period: 4-8 weeks minimum
• PCT: Required immediately after the cycle ends

Timing: Take with food to support absorption and reduce the likelihood of gastrointestinal discomfort.

Cycle support: Although 4-Andro is non-methylated and does not carry the liver burden of methylated compounds, on-cycle support supplements addressing cardiovascular markers and general health are commonly used by experienced prohormone cyclists. This is a personal discretion decision consult a healthcare professional for guidance specific to your health history.

Post-Cycle Therapy (PCT) - Why It Is Mandatory

PCT is not optional. This needs to be understood clearly before purchasing.

When you introduce exogenous testosterone precursors through prohormone use, the body's natural hormone regulation system specifically the hypothalamic-pituitary-gonadal (HPG) axis detects the elevated androgen environment and responds by reducing its own testosterone production signal. This is called suppression.

When the cycle ends and the exogenous prohormone is cleared, testosterone production does not automatically return to normal immediately. Without PCT, the body can remain in a suppressed state meaning endogenous testosterone production is below its natural baseline for weeks. This suppressed phase is associated with muscle loss, fatigue, mood changes, and reduced libido.

PCT supplements work by signalling the HPG axis to resume normal production. Common PCT approaches include selective estrogen receptor modulators (SERMs) and aromatase inhibitors (AIs). LG Sciences' own recommended PCT product is their FormX or similar PCT formulation.

PCT begins immediately after the cycle ends the day after your last tablet. Waiting allows the suppression period to deepen unnecessarily.

Quick Take - Cycle Protocol

• Beginners: 1 tablet/day for 4-6 weeks → 4–8 weeks off → PCT throughout off-period
• Advanced: 2 tablets/day for 6-8 weeks → 4–8 weeks off → PCT throughout off-period
• Never stack multiple prohormones without significant prior experience and healthcare guidance
• Do not extend cycles beyond 8 weeks under any circumstances
• PCT is mandatory not optional

Side Effects and Safety

Understanding the side effect profile of 4-Andro before cycling is not optional reading.

Androgenic side effects:

• Acne particularly on the back, chest, and shoulders
• Accelerated male-pattern hair loss in those with a genetic predisposition
• Increased body hair
• Increased aggression and irritability particularly at higher doses

Estrogenic side effects (from testosterone aromatization):

• Water retention and bloating 4-Andro has a wet-gains profile
• Potential gynecomastia in individuals highly sensitive to estrogen monitoring during cycle is advisable
• Estrogen-sensitive individuals should consider an AI during the cycle

Hormonal suppression:

• Natural testosterone production is suppressed during the cycle this is the reason PCT is mandatory, not optional

Cardiovascular:

• Elevated red blood cell count is possible with androgenic compounds, which can affect blood viscosity
• Blood pressure monitoring during cycle is advisable

Not liver-toxic in the way methylated compounds are but this does not mean the liver is entirely unaffected. Cycle support is a reasonable precaution.

Stop use and consult a healthcare professional immediately if you experience severe mood changes, chest pain, shortness of breath, significant blood pressure elevation, or any other unexpected physical symptoms during a cycle.

This product is not intended to diagnose, treat, cure, or prevent any disease or medical condition.

Where 4-Andro Fits in a Training and Supplement Stack

4-Andro is a cycle-based compound that works within not instead of a structured training and nutrition program. The hormonal environment it creates is most productive when the fundamentals are already in place.

During cycle, prioritise:

• High-protein nutrition protein supplementation to support muscle protein synthesis in an elevated anabolic environment
• Structured resistance training progressive overload during the cycle period maximises the training stimulus
• Creatine can be used throughout the cycle and during PCT, no interaction concerns with non-methylated prohormones
• Adequate sleep hormonal support supplements work most effectively when recovery is not compromised

During PCT:

• Maintain training intensity to preserve muscle gained during the cycle
• Keep protein intake high
• Prioritise sleep and stress management as the HPG axis recovers

Browse our prohormones and cycle support collection for on-cycle support and PCT products compatible with an LG Sciences 4-Andro cycle.

Frequently Asked Questions

1. What is 4-Andro and how does it work?

4-Andro (3β-hydroxy-androst-4-ene-17-one) is a non-methylated prohormone a compound the body converts into testosterone through a two-step enzymatic process. It is a DHEA derivative that enters the body's existing steroid hormone synthesis pathway. It is not testosterone itself but a precursor the body processes into testosterone after ingestion. It is a cycle-based supplement requiring post-cycle therapy after each use period.

2. Is LG Sciences 4-Andro legal?

4-Androsterone is currently sold legally as a dietary supplement in the United States. It is classified differently from the explicitly banned anabolic steroids under the DASCA 2014 legislation as a DHEA derivative. However, the regulatory landscape is subject to ongoing interpretation. Users outside the United States should verify the legal status of this compound in their country before purchasing, as laws vary significantly. This does not mean it is appropriate for athletes in tested sports see the drug testing section.

3. Is PCT really mandatory, or just recommended?

PCT is mandatory. During a prohormone cycle, the body's natural testosterone production is suppressed as it detects the elevated androgen environment. When the cycle ends, production does not automatically recover immediately. Without PCT, users face a period of below-baseline endogenous testosterone associated with muscle loss, fatigue, mood changes, and reduced libido. PCT signals the hypothalamic-pituitary-gonadal axis to resume normal function. Begin PCT the day after your last tablet.

4. Will 4-Andro cause water retention?

4-Andro has a wet-gains profile. Because testosterone the conversion product can aromatize to estrogen, water retention is a realistic side effect, particularly at higher doses or in users who are more sensitive to estrogen. Users who want to minimise water retention during a cycle often incorporate an aromatase inhibitor or estrogen management product alongside 4-Andro. This is standard practice for wet-profile prohormone cycles.

5. Can women use LG Sciences 4-Andro?

No. 4-Andro converts to testosterone. In women, elevated testosterone causes virilisation effects including voice deepening, facial hair growth, clitoral enlargement, and disruption of the menstrual cycle. Some of these effects are irreversible. This product is not for women under any circumstances.

6. Why is the minimum age 21 and not 18?

The endocrine system continues developing through the early twenties. The HPG axis the hormonal regulation system governing testosterone, LH, and FSH is not fully mature until approximately 21 years of age. Introducing exogenous hormone precursors before this developmental window closes risks disrupting natural hormonal maturation in ways that may not be easily corrected. Once hormonal maturity is reached post-21, this developmental risk is substantially reduced.

7. What makes LG Sciences 4-Andro different from generic 4-Andro capsules?

The delivery system. LG Sciences uses a liposome tablet format incorporating Phosphatidylcholine 75% and Hydroxypropyl Beta Cyclodextrin (HPBCD) both bioavailability-enhancing technologies that protect the active compound during digestion and improve absorption at the intestinal level. Non-methylated prohormones have naturally limited oral bioavailability due to first-pass metabolism. The liposome system addresses this without introducing the liver toxicity that methylated compounds use the 17α-methyl modification to overcome.

8. Can 4-Andro be used in tested sports?

No. WADA prohibits testosterone and its precursors, including prohormone compounds that convert to testosterone. Any athlete competing under WADA-compliant anti-doping rules including Olympic sports, most professional sports, and a significant number of amateur organisations must not use this product. The US Military also prohibits prohormone use. NCAA and most collegiate sport organisations ban anabolic agents in this category. If you are subject to any drug testing, do not use this product.

9. How long should the off-cycle period be?

A minimum of 4-8 weeks off after each cycle, with PCT running throughout the off-period. The off-period serves two purposes: allowing the HPG axis to fully recover natural testosterone production and allowing androgen receptors to restore sensitivity. Shortening the off-period or running back-to-back cycles without adequate recovery increases the risk of prolonged suppression and reduces the effectiveness of subsequent cycles.

10. Can 4-Andro be stacked with other compounds?

Experienced users sometimes stack 4-Andro with other prohormones for different synergistic effects for example, combining with 1-Andro for a dry-gains profile that offsets 4-Andro's wet-gains tendency. However, stacking multiple prohormone compounds in the same cycle significantly increases the complexity of the hormonal impact and the importance of proper PCT. Stacking is not appropriate for first-time prohormone users. LG Sciences offers their Bulking Andro Kit, which includes complementary compounds in a pre-designed cycle structure.

CONCLUSION

You now have a complete and honest picture of what LG Sciences 4-Andro is what it does at the molecular level, why the liposome delivery system matters, the full side effect profile, the mandatory PCT requirement, the legal and drug testing context, and who this product is and is not appropriate for. It is a non-methylated prohormone with a well-understood conversion pathway, a superior delivery system within its category, and a usage protocol that demands commitment to the full cycle including post-cycle therapy. If you meet the eligibility criteria adult male, 21+, no relevant health conditions, not subject to drug testing and are prepared to approach it correctly, 4-Andro represents one of the more thoughtfully formulated options in the prohormone space.

FDA DISCLAIMER

(Place at the bottom of the page, above the reviews section)

Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease or medical condition. This product is intended for healthy adult men aged 21 and above only. Not for use by women. Always consult a qualified healthcare professional before beginning any prohormone cycle, particularly if you have pre-existing health conditions or take prescription medications. Post-cycle therapy is mandatory following each cycle.