Blackstone Labs Metha-Quad Extreme – 30 Tablets | 1-Andro & 4-Andro

Blackstone Labs Metha-Quad Extreme is a four-ingredient prohormone formulation combining androsterone, 1-Andro, 4-Andro, and Arimistane in a 300 mg active-ingredient combination per tablet. The product brings together three androgen-related steroid compounds and one steroidal ingredient marketed for its potential effects on aromatase activity.

Unlike proprietary prohormone blends that conceal individual ingredient amounts, Metha-Quad Extreme discloses the quantity of each active ingredient.

Each bottle contains 30 tablets, providing 30 single-tablet servings.

What Is Blackstone Labs Metha-Quad Extreme?

Metha-Quad Extreme is a bodybuilding supplement formulated around several steroid hormone pathways.

Its four active ingredients are:

• Androsterone — 150 mg

• 1-Androstene-3β-ol,17-one (1-Andro) — 50 mg

• 4-Androstene-3β-ol,17-one (4-Andro) — 50 mg

• Androsta-3,5-diene-7,17-dione (Arimistane) — 50 mg

The manufacturer markets this combination for muscle development, strength-focused resistance training, and physique-oriented bodybuilding.

However, the product's complete formulation has not been evaluated in controlled human clinical trials establishing its effects on muscle mass, strength, or hormone concentrations.

Metha-Quad Extreme Ingredients Explained

Androsterone – 150 mg

Androsterone is a naturally occurring steroid metabolite chemically identified as 3α-hydroxy-5α-androstan-17-one.

It belongs to the family of 5α-reduced androgen metabolites and is associated with the metabolism of testosterone and dihydrotestosterone (DHT).

DHT is an androgen hormone that interacts with androgen receptors in several tissues, including reproductive tissues, skin, and skeletal muscle.

Androsterone itself generally exhibits substantially weaker androgenic activity than DHT.

Although androsterone is marketed in certain bodybuilding formulations as a DHT-related precursor, its inclusion does not establish that orally administered androsterone produces meaningful increases in DHT or improvements in muscular performance.

Metha-Quad Extreme provides 150 mg of androsterone per tablet, making it the largest individual ingredient by declared weight.

1-Androstenolone (1-Andro) – 50 mg

1-Androstenolone, also known as 1-Andro or 1-DHEA, is chemically identified as 1-Androstene-3β-ol,17-one.

The compound is associated with steroid metabolic pathways involving 1-testosterone, also known as dihydroboldenone.

1-Testosterone is chemically distinct from conventional testosterone and belongs to the anabolic-androgenic steroid family.

The proposed conversion of 1-Andro involves enzyme-mediated transformations into other androgen-related metabolites.

However, the extent of this conversion following oral supplementation depends on multiple physiological factors.

The presence of 50 mg of 1-Andro does not establish a predictable increase in 1-testosterone concentrations or clinically meaningful muscle development.

4-Androstenolone (4-Andro) – 50 mg

4-Androstenolone, commonly called 4-Andro or 4-DHEA, is a steroid hormone precursor associated with testosterone biosynthesis.

Its chemical identity is 4-Androstene-3β-ol,17-one.

4-Andro participates in metabolic pathways associated with androstenediol, androstenedione, and testosterone.

Testosterone is a biologically active androgen involved in muscle protein metabolism, skeletal muscle physiology, bone health, and reproductive function.

However, supplementing with a testosterone precursor is not equivalent to administering testosterone itself.

Conversion efficiency, resulting hormone concentrations, and biological effects vary according to the compound's absorption and metabolism.

The 50 mg quantity in Metha-Quad Extreme is disclosed, but controlled human data establishing its specific effects within this formulation remain insufficient.

Arimistane – 50 mg

The fourth ingredient is Androsta-3,5-diene-7,17-dione, commonly marketed as Arimistane.

Arimistane is a steroidal compound promoted in bodybuilding supplements for its potential aromatase-inhibiting activity.

Aromatase is an enzyme responsible for converting certain androgen hormones into estrogens.

This process is an important component of normal endocrine regulation in both men and women.

Although Arimistane is marketed as an estrogen-management ingredient, reliable clinical research demonstrating predictable reductions in estradiol or improvements in testosterone concentrations from this specific oral formulation is limited.

Its inclusion should not be interpreted as evidence that Metha-Quad Extreme prevents estrogen-related effects or eliminates hormonal side effects.

How Does Metha-Quad Extreme Work?

Metha-Quad Extreme combines compounds associated with three areas of steroid metabolism.

1. DHT-related metabolism

Androsterone is a naturally occurring metabolite associated with the metabolism of 5α-reduced androgens.

2. Testosterone and 1-testosterone precursor pathways

4-Andro is associated with pathways toward conventional testosterone, while 1-Andro is associated with pathways involving 1-testosterone-related metabolites.

3. Estrogen-related enzyme activity

Arimistane is marketed for potential interaction with aromatase-related pathways.

These mechanisms explain the rationale behind the manufacturer's formulation.

However, combining several androgen-related substances does not establish beneficial synergy, enhanced anabolic potency, or protection from hormonal adverse effects.

Metha-Quad Extreme vs. Single-Ingredient Prohormones

Metha-Quad Extreme differs from single-compound products because it combines multiple androgen-related ingredients in the same tablet.

For example, Blackstone Labs Chosen1 focuses on 1-DHEA derivatives, while Brutal 4ce contains several forms of 4-DHEA.

Metha-Quad Extreme includes both 1-Andro and 4-Andro, along with androsterone and Arimistane.

Another important difference is ingredient transparency.

Chosen1 and Brutal 4ce use proprietary blends that do not disclose the individual quantities of their active compounds.

Metha-Quad Extreme specifies each ingredient amount, allowing a more direct assessment of its declared composition.

However, greater ingredient transparency does not establish greater effectiveness or safety.

Liposomal Delivery Ingredients

Blackstone Labs markets Metha-Quad Extreme with liposomal delivery technology.

The formula includes phosphatidylcholine and hydroxypropyl-beta-cyclodextrin among its other ingredients.

Phosphatidylcholine is a phospholipid commonly used in lipid-based delivery systems.

Hydroxypropyl-beta-cyclodextrin is a modified cyclodextrin capable of forming complexes with certain molecules, potentially changing their solubility characteristics.

Although these substances have established uses in pharmaceutical formulation science, their inclusion does not independently demonstrate improved absorption of Metha-Quad Extreme.

The degree of oral bioavailability, systemic exposure, and hepatic first-pass metabolism would require product-specific pharmacokinetic studies to establish.

Metha-Quad Extreme and Bodybuilding

Blackstone Labs markets Metha-Quad Extreme toward experienced resistance-training enthusiasts interested in prohormone formulations.

The product's manufacturer-marketed applications include:

• Muscle development and lean mass

• Strength-focused resistance training

• Physique and body composition

• Androgen-related metabolic pathways

• Performance-oriented bodybuilding

These are promotional objectives, not clinically demonstrated outcomes of the finished formulation.

Individual hormonal responses and adverse effects cannot be reliably predicted from the product's ingredient quantities alone.

Blackstone Labs Metha-Quad Extreme Supplement Facts

Serving Size: 1 Tablet
Servings Per Container: 30
Container Size: 30 Tablets

Amount Per Serving

Ingredient	Amount
Androsterone	150 mg
1-Androstene-3β-ol,17-one (1-Andro)	50 mg
4-Androstene-3β-ol,17-one (4-Andro)	50 mg
Androsta-3,5-diene-7,17-dione (Arimistane)	50 mg

Total Declared Active Ingredients: 300 mg per tablet.

Daily Values not established.

Other Ingredients: Microcrystalline Cellulose, Phosphatidylcholine, Hydroxypropyl-beta-cyclodextrin (HPβCD), Phytosterol, Stearic Acid, Magnesium Stearate, Starch, Titanium Dioxide, Silica, FD&C Red #40, FD&C Yellow #6.

Allergen Information: According to the documented manufacturer label, this product is manufactured on shared equipment that also processes eggs, wheat, and soy (lecithin).

Frequently Asked Questions

Q: What ingredients are in Metha-Quad Extreme?

A: Each tablet contains 150 mg of androsterone, 50 mg of 1-Andro, 50 mg of 4-Andro, and 50 mg of Arimistane. These four ingredients total 300 mg per serving.

Q: Does Metha-Quad Extreme contain 1-Andro and 4-Andro?

A: Yes. The formula contains both 1-Androstene-3β-ol,17-one (1-Andro) and 4-Androstene-3β-ol,17-one (4-Andro). These compounds belong to different androgen precursor pathways and should not be considered interchangeable.

Q: Is Arimistane included in Metha-Quad Extreme?

A: Yes. Each tablet contains 50 mg of Androsta-3,5-diene-7,17-dione, commonly marketed as Arimistane. Its effectiveness for controlling estrogen concentrations in humans has not been established for this formulation.

Safety and Regulatory Considerations

Metha-Quad Extreme contains steroid-related compounds with potentially significant endocrine and metabolic effects.

Potential risks associated with androgen precursors include suppression of endogenous hormone production, reproductive effects, adverse blood lipid changes, cardiovascular complications, androgen-related adverse effects, and possible liver injury.

The inclusion of Arimistane does not establish protection against estrogen-related effects or other endocrine complications. Altering estrogen metabolism can itself have health consequences.

The finished product has not been adequately evaluated in controlled human studies for long-term safety or effectiveness.

The regulatory classification of steroid-related ingredients and their status under athletic anti-doping regulations should be independently verified.

Consult a qualified healthcare professional before considering products containing androgen precursors.